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Enthalpy is a measure of the total thermal energy of a system and is often represented by the symbol H. Entropy is a measure of the randomness or disorder of a system and is often represented by the symbol S. The change in these quantities during a chemical reaction can be used to determine the spontaneity and equilibrium of the reaction. The relationship between enthalpy and entropy can be described by the Gibbs free energy equation, which states that the change in Gibbs free energy (G) of a system is equal to the change in enthalpy (H) minus the temperature (T) times the change in entropy (S). This equation can be used to determine the conditions under which a reaction is spontaneous or not.