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Here's how to calculate the required amount of Carindacillin Sodium:
1. Calculate the total dosage:
- Dosage rate: 0.50 mg/kg body weight/minute
- Patient weight: 75.0 kg
- Infusion time: 12 hours = 720 minutes
- Total dosage = (0.50 mg/kg/min)
(75.0 kg)
(720 min) = 27,000 mg
2. Convert the dosage to Carindacillin Sodium:
- Molecular weight of Carindacillin: 493.6 g/mol
- Molecular weight of Carindacillin Sodium: 516.6 g/mol
- Dosage of Carindacillin Sodium = (27,000 mg Carindacillin)
(516.6 g/mol Carindacillin Sodium) / (493.6 g/mol Carindacillin) = 28,083 mg
Therefore, you would need 28,083 mg of Carindacillin Sodium to infuse a 75.0 kg patient at the specified rate over 12 hours.