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How to avoid homocoupling of 4-cyanophenylboronic acid in a Suzuki reaction with an heteroaryl chloride and XPhos pd G3?
Accepted Answer
Homocoupling of 4-cyanophenylboronic acid can be minimized by using a low concentration of the boronic acid, a high concentration of the heteroaryl chloride, and a slow addition of the boronic acid to the reaction mixture. Additionally, using a base that is less prone to promote homocoupling, such as potassium phosphate, can also be beneficial. The use of a catalyst that is highly selective for Suzuki-Miyaura reactions, such as XPhos Pd G3, can also help to minimize homocoupling. Finally, carefully controlling the reaction temperature and time can also help to reduce homocoupling.
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