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Is an inert atmosphere necessary when working with P2O5, or can you also do a reaction in an anhydrous solvent, like pyridine?
Accepted Answer
Phosphorus pentoxide (P2O5) is a powerful desiccant and highly reactive with water. While anhydrous solvents like pyridine can be used for certain reactions involving P2O5, it's crucial to minimize exposure to moisture. An inert atmosphere (like nitrogen or argon) is often preferred to prevent hydrolysis and ensure controlled reaction conditions.
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