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What is the function of FAD in the pyruvate dehydrogenase complex and how is it regenerated
Accepted Answer
FAD (flavin adenine dinucleotide) is a coenzyme in the pyruvate dehydrogenase complex. It acts as an electron acceptor, getting reduced to FADH2 during the conversion of pyruvate to acetyl-CoA. This reduction step involves the transfer of two electrons and two protons from the substrate.
FADH2 is then reoxidized back to FAD by the electron transport chain, where it donates its electrons to complex II. This process generates a proton gradient across the inner mitochondrial membrane, which is used to produce ATP through oxidative phosphorylation.
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