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TISAB (Total Ionic Strength Adjustment Buffer) is a buffer solution used in potentiometric measurements to maintain a constant ionic strength in the solution. It is typically used in conjunction with ion-selective electrodes (ISEs) to eliminate or minimize the effects of ionic strength on the electrode's response. TISAB helps to ensure that the electrode's response is primarily determined by the concentration of the target ion, rather than by variations in the ionic strength of the solution. By maintaining a constant ionic strength, TISAB helps to improve the accuracy and precision of the potentiometric measurements.