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When to use gc versus hplc
Accepted Answer
HPLC is generally used for the analysis of polar compounds, while GC is generally used for the analysis of nonpolar compounds. HPLC separates compounds based on their polarity, while GC separates compounds based on their volatility. HPLC is typically used for the analysis of compounds that are soluble in water, while GC is typically used for the analysis of compounds that are soluble in organic solvents. HPLC is typically used for the analysis of compounds that are thermally stable, while GC is typically used for the analysis of compounds that are thermally labile.
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