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Why do we used absolute ethanol in the preparation of benzocaine? With references.
Accepted Answer
Absolute ethanol (100% ethanol) is typically used in the preparation of benzocaine due to its role as a solvent and reaction medium. Here's why:
1. Solubility: Benzocaine is more soluble in absolute ethanol than in water. This allows for efficient dissolution of the starting materials and intermediates during the synthesis process.
2. Reaction Conditions: The reaction to produce benzocaine often involves the use of strong acids or bases. Absolute ethanol provides a suitable environment for these reactions, avoiding unwanted side reactions that could occur in water.
3. Purity: Absolute ethanol ensures a higher purity of the final benzocaine product. Water can interfere with the reaction and lead to impurities.
4. Safety: In some cases, the use of absolute ethanol might be preferred for safety reasons. Water can react with certain reagents, producing unwanted byproducts or potentially hazardous conditions.
References:
Comprehensive Organic Chemistry: This textbook provides detailed information about the synthesis and properties of benzocaine.
Merck Index: This reference book contains information about the synthesis and properties of various chemicals, including benzocaine.
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