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Why does fructose have 2 entry points in glycolysis?
Accepted Answer
Fructose enters glycolysis at a different point than glucose. It is first phosphorylated by fructokinase to fructose-1-phosphate. This is then cleaved by aldolase B into glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. Both of these molecules are intermediates in the glycolytic pathway. Therefore, fructose has two entry points into glycolysis because it can be processed through the aldolase B pathway, bypassing the initial steps of glucose metabolism.
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