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Questions asked by users might not always be phrased in the clearest way.
Why does fructose have two entry points in glycolysis?
Accepted Answer
Fructose has two entry points in glycolysis because it can be phosphorylated by either hexokinase or fructokinase. Hexokinase phosphorylates fructose at the 6th carbon, forming fructose-6-phosphate, which then enters the normal glycolytic pathway. Fructokinase, on the other hand, phosphorylates fructose at the 1st carbon, yielding fructose-1-phosphate. This pathway is specific to fructose and leads to the formation of glyceraldehyde-3-phosphate and dihydroxyacetone phosphate, which are both intermediates in glycolysis.
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