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Prepare a suppository containing 100mg of phenobarbital (f=0.81) using cocoa butter as the base. the weight of the pure cocoa butter suppository is 2.0g. because 100mg of phenobarbital is to be contained in an approximately 2.0g-suppository, it will be about 5% phenobarbital. what will be the total weight of each suppository?
Accepted Answer
The total weight of each suppository will be approximately 2.12 g. Here's how to calculate it:
1. Calculate the weight of phenobarbital needed:
You need 100 mg of phenobarbital, and its fraction (f) is 0.81.
Weight of phenobarbital = 100 mg / 0.81 = 123.46 mg
2. Calculate the weight of cocoa butter needed:
The weight of the pure cocoa butter suppository is 2.0 g (2000 mg).
Weight of cocoa butter needed = 2000 mg - 123.46 mg = 1876.54 mg
3. Calculate the total weight of the suppository:
Total weight = Weight of phenobarbital + Weight of cocoa butter
Total weight = 123.46 mg + 1876.54 mg = 2000 mg = 2.0 g
Therefore, the total weight of each suppository will be approximately 2.0 g.
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