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Synthesis of tetrapotassium iminodisuccinate was performed in two steps: the first step involves the addition of 8 ml of water and 4.4 g of KOH sequentially to 4.6 g of maleic anhydride, stirring for 1 hour at 50°c. the second step requires gradually heating the temperature to 110°c and stirring for 0.5 hour for the cyclization process. which ph is more suitable for the last step?
Accepted Answer
A higher pH is more suitable for the cyclization step. The cyclization reaction likely involves the formation of an imide bond, which is favored under basic conditions. The increased concentration of hydroxide ions (OH-) at a higher pH promotes the deprotonation of the amine group and enhances nucleophilic attack on the carbonyl group, leading to the formation of the imide ring.
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