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Write short note on the reactivity of aldehydes and ketones on steric group
Accepted Answer
The reactivity of aldehydes and ketones is significantly influenced by steric hindrance. Bulky groups near the carbonyl group (C=O) can hinder the approach of nucleophiles, decreasing the rate of reaction. This is because steric hindrance makes it more difficult for the nucleophile to access the electrophilic carbon atom of the carbonyl group. For example, a ketone with two large alkyl groups will be less reactive than a ketone with two small alkyl groups. This effect is particularly important in reactions involving nucleophilic attack on the carbonyl group, such as the addition of Grignard reagents, Wittig reactions, and aldol condensations.
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