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How can i rule out production of aspartic acid or succinic acid during synthesis of iminodisuccinic acid from ammonium bicarbonate and fumaric acid in methanol at the presence of tbab?
Accepted Answer
The production of aspartic acid or succinic acid during the synthesis of iminodisuccinic acid (IDS) from ammonium bicarbonate and fumaric acid in methanol with tetrabutylammonium bromide (TBAB) is unlikely due to the reaction mechanism. IDS formation involves a nucleophilic attack of the ammonium bicarbonate on the fumaric acid double bond, followed by ring closure. This mechanism does not directly favor the formation of aspartic acid or succinic acid. The presence of TBAB as a phase-transfer catalyst facilitates the reaction by increasing the solubility of the reactants in the methanol medium. While side reactions are always possible, the specific reaction conditions and the mechanism involved strongly suggest that aspartic acid or succinic acid production would be minimal.
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