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Monochloroacetone can be synthesized via chlorination of acetone using chlorine gas in the presence of a catalyst like ferric chloride (FeCl3). The reaction proceeds through a free radical mechanism. The reaction can be represented as:
CH3COCH3 + Cl2 → CH3COCH2Cl + HCl
This reaction is exothermic and can be carried out at room temperature or slightly elevated temperatures. The reaction is typically carried out in an inert solvent such as carbon tetrachloride or chloroform.