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Monochloroacetone can be synthesized by the chlorination of acetone using chlorine gas without a catalyst. The reaction is typically carried out in the presence of a solvent, such as water or acetic acid, and at a temperature between 0 and 25 degrees Celsius. The reaction proceeds via a free radical mechanism, and the product is a mixture of monochloroacetone and dichloroacetone. The yield of monochloroacetone can be improved by using a stoichiometric amount of chlorine and by removing the dichloroacetone from the reaction mixture as it is formed.